Terretonin N: A New Meroterpenoid from Nocardiopsis sp.

نویسندگان

  • Abdelaaty Hamed
  • Ahmed S Abdel-Razek
  • Marcel Frese
  • Hans Georg Stammler
  • Atef F El-Haddad
  • Tarek M A Ibrahim
  • Norbert Sewald
  • Mohamed Shaaban
چکیده

Terretonin N (1), a new highly oxygenated and unique tetracyclic 6-hydroxymeroterpenoid, was isolated together with seven known compounds from the ethyl acetate extract of a solid-state fermented culture of Nocardiopsis sp. Their structures were elucidated by spectroscopic analysis. The structure and absolute configuration of 1 were unambiguously determined by X-ray crystallography. The isolation and taxonomic characterization of Nocardiopsis sp. is reported. The antimicrobial activity and cytotoxicity of the strain extract and compound 1 were studied using different microorganisms and a cervix carcinoma cell line, respectively.

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عنوان ژورنال:
  • Molecules

دوره 23 2  شماره 

صفحات  -

تاریخ انتشار 2018